John/Heather Saunders: Main character; 14; changes into a girl because of a rare genetic condition, Orlando Syndrome Duncan Saunders: John/Heather's father; CPA; supports John through his transformation into Heather Margie Saunders: John/Heather's mother; nurse; supports John through his transformation into Heather, and teaches her about being a girl Caitlin Saunders: John/Heather's big sister; 16; takes her under her wing Patty and Chuck Saunders: John/Heather's younger siblings; fraternal twins; 8; find out that they have Orlando Syndrome, and will change sex when they are 14 Dan Anderson: John's best friend; 14; deals with his changing feelings as his best friend becomes a girl Becky Buckley: John/Heather's friend; 14; helps Heather find her sense of style Melanie Stine: John/Heather's friend; 14; trans Keiko Hosokawa: John/Heather's friend; 14; also has Orlando Syndrome; changed into a girl in her native Japan Dr. Ramsey: Physician; specialist in Orlando Syndrome; treats the Saunders siblings who have Orlando Syndrome
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